To take back or away, as what has been bestowed or enjoyed; to draw back; to cause to move away or retire; as, to withdraw aid, favor, capital, or the like. [1913 Webster] Impossible it is that God should withdraw his presence from anything. --Hooker. [1913 Webster]
To take back; to recall or retract; as, to withdraw false charges. [1913 Webster]
Withdraw \With*draw"\, v. i. To retire; to retreat; to quit a company or place; to go away; as, he withdrew from the company. "When the sea withdrew." --King Horn. [1913 Webster] Syn: To recede; retrograde; go back. [1913 Webster]
1 pull back or move away or backward; "The enemy withdrew"; "The limo pulled away from the curb" [syn: retreat, pull away, draw back, recede, pull back, retire, move back]
2 withdraw from active participation; "He retired from chess" [syn: retire]
3 release from something that holds fast, connects, or entangles; "I want to disengage myself from his influence"; "disengage the gears" [syn: disengage] [ant: engage]
4 cause to be returned; "recall the defective auto tires"; "The manufacturer tried to call back the spoilt yoghurt" [syn: recall, call in, call back]
6 keep away from others; "He sequestered himself in his study to write a book" [syn: seclude, sequester, sequestrate]
7 remove something concrete, as by lifting, pushing, taking off, etc. or remove something abstract; "remove a threat"; "remove a wrapper"; "Remove the dirty dishes from the table"; "take the gun from your pocket"; "This machine withdraws heat from the environment" [syn: remove, take, take away]
8 break from a meeting or gathering; "We adjourned for lunch"; "The men retired to the library" [syn: adjourn, retire]
9 retire gracefully; "He bowed out when he realized he could no longer handle the demands of the chairmanship" [syn: bow out]
10 remove (a commodity) from (a supply source); "She drew $2,000 from the account"; "The doctors drew medical supplies from the hospital's emergency bank" [syn: draw, take out, draw off] [ant: deposit]
11 lose interest; "he retired from life when his wife died" [syn: retire]
12 make a retreat from an earlier commitment or activity; "We'll have to crawfish out from meeting with him"; "He backed out of his earlier promise"; "The aggressive investment company pulled in its horns" [syn: retreat, pull back, back out, back away, crawfish, crawfish out, pull in one's horns] [also: withdrew, withdrawn]
Moby Thesaurusabandon, abate, abdicate, abjure, abolish, abrade, abrogate, abrupt, abscond, abstract, agree to differ, agree to disagree, alienate, annul, avulse, back down, back out, backwater, bate, be at variance, be in dissent, be pensioned, be superannuated, beat a retreat, become an individual, beg off, beg to differ, blow, bow out, cancel, cast off, cast out, climb down, countermand, counterorder, crawfish out, cringe, cry off, curtail, cut adrift, cut off, cut out, decline, decrease, deduct, delete, demit, deny, depart, depart from, depreciate, deracinate, derogate, detract, die away, differ, dig out, dig up, diminish, disagree, disagree with, disannul, disappear, disarticulate, disavow, discard, disclaim, disconnect, discord with, disengage, disentangle, disjoin, disjoint, disown, disparage, dissent, dissent from, dissociate, disunite, divide, divide on, divorce, do away with, drain, draw, draw back, draw in, draw off, draw out, dredge, dredge up, drift away, drop out, duck, dwindle, eat away, eat crow, eat humble pie, ebb, eject, eradicate, erode, estrange, evacuate, evolve, evulse, excavate, excise, exit, expel, exsect, extract, extricate, fade, fade away, fall back, file away, flinch, forsake, forswear, get away, get off, get out, give back, give ground, give place, give up, give way, go, go away, go back, go back on, gouge out, grub up, impair, invalidate, isolate, jettison, jilt, keep apart, leach, leave, leave behind, leave flat, lessen, make void, maroon, mine, move away, move back, move off, not agree, nullify, oppose, override, overrule, palinode, part, pension off, pick out, pluck out, pluck up, pull, pull away, pull back, pull in, pull out, pull up, purify, quail, quarry, quit, quit cold, rake out, recall, recant, recede, recoil, reduce, refine, relinquish, remove, renege, renounce, renounce the throne, repeal, repudiate, rescind, resign, retire, retire from office, retract, retreat, retrench, retrocede, reverse, revoke, rip out, root out, root up, rub away, run along, run back, say goodbye to, secede, segregate, separate, sequester, set apart, set aside, shorten, shrink, shut off, shy, sink, split, stand alone, stand aloof, stand apart, stand aside, stand back, stand down, stand off, step aside, subduct, subtract, superannuate, suspend, swallow, take away, take back, take exception, take from, take issue, take leave of, take off, take out, tear out, thin, thin out, throw off, throw out, throw over, uncouple, unearth, unravel, unsay, unyoke, uproot, vacate, vanish, void, waive, wane, wear away, weed, weed out, widen the distance, wince, withdraw from, withhold assent, wrest out, write off
remove, stop providing
extract (money from an account)
- For other meanings, see Withdrawal (disambiguation).
Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage. The term can also, less formally, refer to symptoms that appear after discontinuing a drug or other substance (unable to cause true physical dependence) that one has become psychologically dependent upon.
OverviewThe sustained use of many kinds of drugs causes reversible adaptations within the body that tend to lessen the drug's original effects over time, a phenomenon known as drug tolerance. To have these adaptations to a drug is to have a physical dependency on it, for when the drug is suddenly discontinued or decreased, the adaptations do not immediately disappear. Unopposed by the drug, the adaptations appear as withdrawal signs and symptoms that are generally the opposite of the drug's direct effects. Depending primarily on the drug's elimination half-life, withdrawal symptoms can appear within a few hours to several days after discontinuation.
The withdrawal symptoms associated with many recreational drugs are well-known. However, many drugs that do not generally cause euphoria, and are therefore not generally abused or thought of as addictive, also induce physical dependence with associated withdrawal. Examples include beta blockers, corticosteroids such as cortisone, many anticonvulsants and most antidepressants. Nevertheless, sudden withdrawal from these medications can be harmful or even fatal; this is why many prescription labels explicitly warn the patient not to discontinue the drug without doctor approval.
Withdrawal from drugs of abuseCentral to the role of nearly all drugs that are commonly abused to produce euphoria is the nucleus accumbens, the brain's "pleasure center". Neurons in the nucleus accumbens use the neurotransmitter dopamine, so while specific mechanisms vary, nearly every drug of abuse either stimulates dopamine release or enhances its activity, directly or indirectly. Sustained use of the drug results in less and less stimulation of the nucleus accumbens until eventually it produces no euphoria at all. Discontinuation of the drug then produces a withdrawal syndrome characterized by dysphoria — the opposite of euphoria — as nucleus accumbens activity declines below normal levels
Withdrawal symptoms can vary significantly among individuals, but there are some commonalities. Subnormal activity in the nucleus accumbens is often characterized by depression, anxiety and craving, and if extreme can help drive the individual to continue the drug despite significant harm — the definition of addiction — or even to suicide
However, addiction is to be carefully distinguished from physical dependence. Addiction is a psychological compulsion to use a drug despite harm that often persists long after all physical withdrawal symptoms have abated. On the other hand, the mere presence of even profound physical dependence does not necessarily denote addiction, e.g., in a patient using large doses of opioids to control chronic pain under medical supervision .
As the symptoms vary, some people are, for example, able to quit smoking "cold turkey" (i.e., immediately, without any tapering off) while others may never find success despite repeated efforts. However, the length and the degree of an addiction can be indicative of the severity of withdrawal
Withdrawal is a more serious medical issue for some substances than for others. While nicotine withdrawal, for instance, is usually managed without medical intervention, attempting to give up a benzodiazepine or alcohol dependency can result in seizures and worse if not carried out properly. An instantaneous full stop to a long, constant alcohol use can lead to delirium tremens, which may be fatal .
An interesting side-note is that while physical dependence (and withdrawal on discontinuation) is virtually inevitable with the sustained use of certain classes of drugs, notably the opioids, psychological addiction is much less common. Most chronic pain patients, as mentioned earlier, are one example. There are also documented cases of soldiers who used heroin recreationally in Vietnam during the war, but who gave it up when they returned home (see Rat Park for experiments on rats showing the same results). It is thought that the severity or otherwise of withdrawal is related to the person's preconceptions about withdrawal. In other words, people can prepare to withdraw by developing a rational set of beliefs about what they are likely to experience. Self-help materials are available for this purpose .
Withdrawal from prescription medicineAs mentioned earlier, many drugs should not be stopped abruptly without the advice and supervision of a physician, especially if the medication induces dependence or if the condition they are being used to treat is potentially dangerous and likely to return once medication is stopped, such as diabetes, asthma, heart conditions and many psychological or neurological conditions, like epilepsy, hypertension, schizophrenia and psychosis. To be safe, consult a doctor before discontinuing any prescription medication.
Sudden cessation of the use of an antidepressant can deepen the feel of depression significantly (see "Rebound" below), and some specific antidepressants can cause a unique set of other symptoms as well when stopped abruptly.
Discontinuation of selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed class of antidepressants, (and the related class serotonin-norepinephrine reuptake inhibitors or SNRIs) is associated with a particular syndrome of physical and psychological symptoms known as SSRI discontinuation syndrome. Effexor (venlafaxine) and Paxil (paroxetine), both of which have relatively short half-lives in the body, are the most likely of the antidepressants to cause withdrawals. Prozac (fluoxetine), on the other hand, is the least likely of SSRI and SNRI antidepressants to cause any withdrawal symptoms, due to its exceptionally long half-life.
ReboundMany substances can cause rebound effects (significant return of the original symptom in absence of the original cause) when discontinued, regardless of their tendency to cause other withdrawal symptoms. Rebound depression is common among users of any antidepressant who stop the drug abruptly, whose states are sometimes worse than the original before taking medication. This is somewhat similar (though generally less intense and more drawn out) than the 'crash' that users of ecstasy, amphetamines, and other stimulants experience. Occasionally light users of opiates that would otherwise not experience much in the way of withdrawals will notice some rebound depression as well. Extended use of drugs that increase the amount of serotonin or other neurotransmitters in the brain can cause some receptors to 'turn off' temporarily or become desensitized, so, when the amount of the neurotransmitter available in the synapse returns to an otherwise normal state, there are fewer receptors to attach to, causing feelings of depression until the brain re-adjusts.
Other drugs that commonly cause rebound are:
- Nasal decongestants, such as Afrin (oxymetazoline) and Otrivin (xylometazoline), which can cause rebound congestion if used for more than a few days
- Many analgesics including Advil, Motrin (ibuprofen), Aspirin (acetylsalicylic acid), Tylenol (acetaminophen or paracetamol), and some prescription but non-narcotic painkillers, which can cause rebound headaches when taken for extended periods of time.
- Sedatives and benzodiazepines, which can cause rebound insomnia when used regularly as sleep aids.
With these drugs, the only way to relieve the rebound symptoms is to stop the medication causing them and weather the symptoms for a few days; if the original cause for the symptoms is no longer present, the rebound effects will go away on their own.
Neonatal abstinence syndromeNeonatal abstinence syndrome (NAS) is a withdrawal syndrome of infants, caused by administration of drugs. There are two types of NAS, prenatal and postnatal. Prenatal NAS is caused by substance abuse by the mother, while postnatal NAS is caused by discontinuation of drugs directly to the infant.
The drugs involved are e.g. opioids, selective serotonin reuptake inhibitors (SSRIs) and alcoholic beverages. to describe signs of withdrawal although the dose remains constant. Such signs may arise in use of benzodiazepines and amphetamine.
withdraw in German: Entzugssyndrom
withdraw in Spanish: Síndrome de abstinencia
withdraw in French: Sevrage (toxicologie)
withdraw in Italian: Crisi d'astinenza
withdraw in Hebrew: גמילה
withdraw in Lithuanian: Abstinencijos sindromas
withdraw in Dutch: Ontwenningsverschijnselen
withdraw in Norwegian: Abstinens
withdraw in Polish: Zespół abstynencyjny
withdraw in Russian: Абстинентный синдром
withdraw in Finnish: Vieroitusoire
withdraw in Turkish: Yoksunluk sendromu